Muzan Kibutsuji/Relationships

Tanjiro Kamado
Tanjiro is considered to be Muzan's main nemesis throughout the series. After murdering the Kamado family, he was personally sought out by Tanjiro in Asakusa, Tokyo when the Demon Slayer recognized his scent from the scene of the murder. Although Muzan had never met Tanjiro before, he knew immediately that he needed to eliminate him after recognizing the hanafuda earrings he wore to be the ones his would-have-been killer previously donned, as later revealed. In an attempt to flee, he created a diversion by transforming a young man into a Demon to deter Tanjiro, but not before Tanjiro professed his goal to chase Muzan to the ends of the earth in order to kill him. Enraged by his threats, Muzan would send multiple Demons to kill Tanjiro such as Yahaba, Susamaru and Enmu throughout the series.

As aforementioned, it is revealed that Muzan's desire to destroy Tanjiro stemmed from his hatred towards his previous nemesis, Yoriichi Tsugikuni, as, after recognizing the earrings Tanjiro wore in Asakusa, Muzan realized that he was a Breath of the Sun user, a wielder of the incredibly powerful technique Yoriichi had developed and that Muzan had sworn to eradicate users of after it almost killed him. This is why, upon seeing Tanjiro for the first time, the Demon Lord felt threatened and became frantic in trying to kill him.

Nezuko Kamado
At the very beginning of the story, Muzan tried to turn Nezuko and the entire Kamado Family into Demons, however all of them but Nezuko failed to survive the transformation and instead passed away. He soon found her to be a defiant nuisance much like Tamayo, able to escape his curse and become uncontrollable. This all changed however, after Nezuko became his "Chosen Demon," developing a resistance to sunlight and Muzan didn't hesitate for a moment to attack the Demon Slayer Corps alongside the remaining Upper Moon Demons in an attempt to devour Nezuko and achieve his long-sought desire to become truly invincible.

Later, as Nezuko regained all of her memories including the painful and traumatizing memories of losing her family to Muzan in his attack on her home, she is shown to harbor immense hatred and rage towards the Demon's actions and was shown to barely be able to control herself as it all came back to her.

Yoriichi Tsugikuni
When he first encountered Yoriichi, Muzan was arrogant and stated that he wasn't interested in Demon Slayers who use Breath Styles, before dismissively attacking Yoriichi as if he'd be an easy kill. However, much to his surprise, Yoriichi struck him multiple times with his bright red blade, wounding him with deep slashes that the Demon Lord was unable to regenerate. Muzan quickly fled the scene, barely still alive, and developed a loathsome fear of the Breath Style Progenitor, prompting him to later convert Yoriichi's older twin brother into a Demon and systematically murder other Breath of the Sun users.

Even 400 years later, Muzan's fear of Yoriichi remained fully intact, as simply laying eyes on Tanjiro's hanafuda earrings caused him to recall their clash. Although Yoriichi was long dead, his visage appeared in the blood memory of Daki after Tanjiro awakened his Demon Slayer Mark, causing Muzan's fear to once again grow.

Tamayo
In their initial encounter, Muzan turned Tamayo into a Demon in order to cure her disease, hiding from her the true consequences of the transformation and so causing the death of her husband and kids. Much like Nezuko, Muzan views her as a nuisance to him after she was freed of his control, and desires for her to be killed. He didn't hesitate to mock Tamayo about killing her husband and children as well as going on a rampage out of despair killing other humans in the process, placing all the blame on her without taking responsibility for any of it.

Prior to this, hundreds of years ago, Tamayo had attempted to kill Muzan. However, upon realizing that she stood absolutely no chance of winning, Tamayo's mental state was completely defeated, her resolve and determination replaced by a docile, servant-like demeanour.

However, upon witnessing Yoriichi's immense power and skill during his fight with Muzan, Tamayo's resolve to kill him was reignited, causing her to once again refocus her efforts onto defeating the Demon Lord and restart her research into creating drugs for weakening or killing him.

Twelve Demon Moons
Muzan holds these Demons in quite a high regard compared to the others, giving them a larger portion of his blood to increase their powers. However, he still doesn't treat any of them as equals, as evidenced by his quick decision to kill all but one of the Lower Moons out of anger after Rui's defeat as he criticized them for their weaknesses, and his verbal abuse towards the Upper Moons after Gyutaro's death for their failure to find the Blue Spider Lily after hundreds of years. He viewed them all as expendable tools despite the immense loyalty all of them had showed towards him.

Upper Moons
The six Demons given the rank of Upper Moon in the Twelve Demon Moons are regarded as Muzan's most favored servants, with the six of them even being regarded as being much more valuable to him in comparison to the six Lower Moons. This is given evidence by the fact that Muzan has given several special privileges to the Upper Moons normally not given to the Lower Moons, such as being allowed into and knowing about the existence of the Dimensional Infinity Fortress and giving them much more leeway & leniency to do what they want when they are assigned specific tasks by the Demon Lord. Muzan is also shown to treat the Upper Moons considerably better in comparison to how badly he degrades those in the Lower Moon ranks.

Kokushibo
Muzan turned Michikatsu into a Demon likely only out of spite toward his twin brother. However, Muzan sees him as something of a business partner.

Daki and Gyutaro
Muzan is shown to have a positive master-servant relationship with Daki, as the young Demoness seemingly worships and admires the Demon Progenitor immensely, fervently hanging on each and every one one of his words and doing her absolute best to accomplish the tasks he gives her.

Muzan, in turn, aware of Daki's easily trusting and therefore exploitable personality, takes full advantage of her worship by regularly complimenting her, calling her a "special" Demon in order to reinforce her loyalty to him. However, in truth, as revealed after her death, Muzan sees Daki as but a tool to keep her brother, Gyutaro, in line, deeming her to be the main reason why the "true" Upper Moon Six was killed and in truth does not think highly of her and deeming her as someone not very intelligent.

Due to his favoritism to the siblings (particularly to Gyutaro), Muzan was noted to give them the special privilege to actually share the position of Upper Moon Six between the two of them, something not even seen among any of the other higher ranked Upper Moons.

In truth, Muzan only ever saw Gyutaro as truly being worthy of being his Upper Moon Six, as revealed when Muzan claims that he highly valued him and expected him to grow more powerful due to his greedy, apathetic and violent personality. However, Muzan also seems to look down on Gyutaro due to him believing that his love for his sister was holding him back and that the main reason he was killed was her.

Gyokko
During the first gathering of the Upper Moons in hundreds of years, Muzan is shown to particularly dislike Gyokko due to his arrogant and somewhat insolent personality clashing with Muzan's own short tempter and narcissism, seen when he angrily ripped off Gyokko's head when the Demon attempted to appease his Lord.

Gyokko, however, despite being brutally beheaded by him, showed absolute loyalty to the Demon Progenitor, as seen when he showed no fear, pain or anger at Muzan's actions but was instead overjoyed by Muzan holding his severed head in one hand. showing a fanatical amount of loyalty to him and was slightly annoyed by Muzan blowing him off despite him obtaining vital information on the Demon Slayer Corps but in the end considered this a good point of Muzan's personality.

Later it was revealed that Muzan in fact considers Gyokko to be one of his favorite Upper Moons due to his pots, with him greatly liking to the artistic skill he puts into them and the high price he gets by selling them.

Hantengu
Hantengu is seen to be incredibly fearful towards Muzan,especially during the Demon Lord's more violent and moody episodes,as seen when he was constantly cowering in fear of him and constantly apologizing to him during the meeting of the Upper Moons after Gyutaro and Daki's deaths putting him in a bad mood. But nonetheless Muzan is still shown to possess a level of trust in Hantengu's abilities and powers as a Demon despite his cowardly nature, as seen when he trusted him enough to accompany Gyokko in a mission after the meeting was adjured.

Later it was revealed that Hantengu follows Muzan not out of fear of him, but due to him being genuinely loyal and grateful to the Demon Lord. This was due to Muzan having "saved" Hantengu from being executed by a "corrupt" Magister who did not believe Hantegnu's claims of being "innocent" of the crimes of theft and murder by transforming him into a Demon and freeing him from prison before his execution date. Thanks to this Hantengu believes that Muzan was the first person to "truly" see his "innocent self" and "believe" him, causing the Demon to then harbor a deep sense of respect that is even present in his other radically different disposition clones.

Upon his death at the hands of Tanjiro Kamado, Muzan was absolutely delighted by Hantengu, due to him successfully reporting that a Demon that can withstand sunlight has appeared, causing the Demon progenitor to laugh in ecstatic delight and actually compliment the Upper Moon on his work.

Muzan in turn sees Hantengu as an "ordinary person" and sees his overly cowardly/submissive personality as annoying, but tolerable.

Nakime
Nakime's exact relationship with Muzan is unknown, but she herself has shown to be incredibly loyal and obedient to the Demon Lord out of genuine loyalty instead of fear, as seen where she would stoically follow each and every order given to her by Muzan without hesitation.

After becoming an Upper Moon and replacing Hantengu, Muzan is shown to have become genuinely impressed and appreciative of Nakime's growth in her abilities and the further development of her powers, as seen where he actually complimented her on her growth and even thanked her for successfully completing her mission of locating each and every Demon Slayer across the country and locating Kagaya Ubuyashiki himself, a rarity due to Muzan's own view of only seeing the Upper Moons as expendable tools and the usual degrading/arrogant/condescending demeanor he usually shows when interacting with them.

She was one of Muzan's favorite Upper Moons, since he believes her ability to be exceptionally useful.

Akaza
Muzan had first met Akaze during the latter's final days as a human under his original name Hakuji, having first met the human man after he had brutally murdered and avenged his teacher and fiance's murders by killing their killers brutally. Muzan having heard of the carnage and the sheer brutality of the mutilated corpses of the victims was under the assumption that a Demon was responsible for the killings, confusing the Demon Lord due to not having sent any into the region of the killing's location causing him to then go to the place in order to investigate out of curiosity.

Eventually after tracking down the killer, Muzan was both surprised and delighted to learn that the killer was in fact nothing more than a normal human, fascinating him enough to then transform the emotionally distraught Hakuji into a Demon and injecting him with a gigantic amount of his blood and invited him to become powerful enough for the new group he was going to form.

Eventually Hakuji now known as Akaza, had fully reached Muzan's expectations and did indeed become one of his Demon Moons, specifically his Upper Moon Three, delighting the Demon Lord and causing him to particularly grant a great amount of his personal favor to Akaza in comparison to his fellow Demon Moons. As stated by Doma, that Muzan had tolerated and allowed Akaza's unique aversion to not eating or harming women and even only went as far as only dispatching him on special missions only, a privilege not even given to Upper Moons One or Two.

He was one of Muzan's favorites since he was loyal and serious.

Doma
During their interaction during the Upper Moons meeting in the wake of Gyutaro and Daki's deaths, Muzan is shown to be just as annoyed, short tempered and degrading towards Doma as he is to the other Upper Moons,where Muzan visibly expresses his anger, frustration, disappointment and withering faith in Doma due to his inability to live up to his expectation of finding the Blue Spider Lily and entombing and wiping out the Demon Slayer Corps and the Ubuyashiki Family for him.

Doma in turn has not displayed any form of fear, anxiety or anger at the Demon Lord despite his attitude towards him and the other Upper Moons or any of the potential punishment he could inflict upon him, in fact Doma himself has not displayed the usual attitude of fear and respect most Demons show Muzan and is instead shown to take a more laid back and comedic disposition when interacting with him, as seen where Doma actually seems to be happy and excited on his potential "punishments" as seen where he enthusiastically offered Muzan if he should gouge out his own eye for him or perform any other form of extreme self harm to himself for the Demon Lord, further angering and annoying Muzan due to his enthusiasm and lack of seriousness/fear when interacting with him.

Muzan never really liked Doma, likely due to him noticing the latter's lack of emotion and desires.

Lower Moons
Muzan's relationship with the Lower Moons of the Twelve Demon Moons is considerably lower and much worse than that of his Upper Moons, with Muzan himself having slowly become displeased with the Lower Moons due to the fact that in comparison to the Upper Moon members who have not been killed and replaced for hundreds of years, the Lower Moons have always suffered casualties to the Demon Slayer Corps and have had their members repeatedly replaced numerous times through the centuries.

Eventually with the death of Rui and the defeat of the Spider Family, Muzan decided to wash his hands free of the Lower Moons and disposed of each and every member due to him finally deeming them to be too "weak" to be of any real use to him.

Rui
Although unknown when, how or why, Muzan became aware of and interested in Rui during his time as a human, specifically the fact that he was born as with a sickly and fragile human body that made even the simplest physical actions, such as walking, difficult and cause him to immediately collapse afterwards in exhaustion. Muzan, possibly empathizing with the young boy due to his own previous maladies and sickly body since birth, approached the weak young man and offered to "cure" him of his weak body, an offer Rui happily agreed to due to wanting to make his parent's happy and worry less for his health without fully knowing what Muzan was offering him. Muzan then gave him his blood and successfully transformed him into a Demon before once again leaving without telling him of the new characteristics and nutritional needs his new body would need, but nonetheless kept a close eye on the fledgling Demon's progress.

Eventually Rui like all Demons eventually began killing people in order to eat them, horrifying his parents who then attempted to kill their son before he could commit any greater atrocities but instead ended up being killed by Rui in self defense within their home. There, Muzan once again appeared before the young Demon who, was going through severe psychological shock and denial of his own actions. Realizing the fragility of Rui's mental state, Muzan proceeded to then manipulate the young Demon by telling him that the two dead humans killed at his own hands weren't his "real" family, "assisting" the young Demon's tormented and guilt-ridden mind by telling him to rationalize that his "true" family would never try to kill him and that he could simply search for a "new" family as a Demon. Eventually obtaining the young Demon's loyalty as a result of him "helping" him.

After these events, Rui continued to kill and devour humans and was eventually awarded with the position of Lower Moons Five among the Twelve Demon Moons. Where Rui soon became something of a favorite of Muzan's. As seen where despite the Demon Lord's usual policy and law of preventing any Demons from banding and teaming up together in large groups, Rui was actually given special permission by Muzan to create his own "family" to satisfy his yearning for one, which then lead to the creation of the Spider Family. A privilege not even given to those of the Upper Moons.