The Twelve Demon Moons are divided into two groups, the Upper Moons (
The Twelve Demon Moons have been given three tasks to complete by Muzan's command:
- To find the Blue Spider Lily (the key ingredient of the experimental medicine that made Muzan a demon); but since Muzan's discovery (via Hantengu Chapter 126) that Nezuko is sun-proof, he has decided that the Upper Moons should focus on capturing her and bring her to him.
- To destroy the Demon Slaying Corps.
- After the failure, to find the Blue Spider Lily or destroy the Demon Slaying Corps. In over a thousand years, he has decided that the demons should serve him with a suicidal devotion to ensuring success.
The Pillars of the Demon Slaying Corps have killed numerous Lower Moons over the years, while the Upper Moons have killed (and eaten) various Pillars as proof of their strength. Since the members of the Upper Moons have not changed for over a hundred years, but at the same time, the members of the Lower Moons have been killed and replaced many times over. Kibutsuji Muzan decided to dismantle the Lower Moons after the most recent failure, the death of Rui (Lower Moon Five), by summoning the remaining Lower Moons to a meeting. Muzan then proceeded to kill the unnamed Lower Moons Two, Three, Four, and Six after their weakness was revealed, sparing only Enmu (Lower Moon One) by giving him a chance to redeem himself by killing a pillar with an injection of his blood. But with Enmu's death by the hands of Tanjirou, the Lower Moons are officially disbanded with all of their members dead.
The first of the Twelve Demon Moons that was encountered in the series was the former Lower Moon 6, Kyogai, who is slain in battle by Tanjiro Kamado. Tanjiro and his companions would shortly thereafter embark to the Natagumo Mountains to face-off against Lower Moon 5, Rui, who was manipulating a group of demons to forcibly act as family figures to himself and to also assist him with the killing of Demon Hunters. Tanjiro would almost manage to behead Rui but unfortunately, the demon outwitted the young hunter by using his threads to cut off his head. He is later saved by the timely arrival of the Water Pillar, Giyuu Tomioka, who swiftly beheads Rui for good. Rui's destruction would later prompt Muzan Kibutsuji to lose his entire faith in the faction's ability and proceeded to dismantle the remaining Lower Moons by coldly annihilating all members except for Lower Moon 1, Enmu.
Enmu is then tasked by Muzan with killing the Pillars and Tanjiro as a last chance offer to save his life, promising to share more of his blood should he complete the mission. Enmu later intercepted Tanjiro with his companions on a train. He planned to combine his body with the train carrying over 200 passengers to use his Demon Blood Technique and trap passengers in their dreams to feast on them en masse. Through the joint effort of Tanjiro Kamado and Inosuke Hashibira, Enmu is soundly defeated, only for their short-lived victory to be interrupted by the unexpected arrival of Upper Moon 3, Akaza. Akaza would commence battle with the Flame Pillar, Kyojuro Rengoku. After a lengthy battle, Akaza would emerge victorious, claiming the life of Kyojuro.
Daki, Upper Moon 6, is the next high ranked demon encountered. After hearing words of a demon claiming its feeding ground in the Red Light District is received by the Sound Pillar, Tengen Uzui, he sets off with the aid of Tanjiro, Nezuko, Inosuke, and Zenitsu. The group manages to locate Daki and were able to slice her neck only for her to reveal her older brother and the true 6th Upper Moon, Gyutaro. Gyutaro and Daki, revealed to be sharing bodies were both finally defeated after a lengthy confrontation by beheading the siblings simultaneously.
Immediately following the deaths of Gyutaro and Daki (Upper Moon Six), Muzan summoned the remaining members of the Upper Moons and gave Hantengu and Gyokko (Upper Moons Four & Five, respectively) a mission to exterminate the Swordsmith's Village, to reduce the power of the Demon Slaying Corps. By removing their ability to fight on par with the demons without swords. Both Hantengu and Gyokko were slain, but not before Hantengu witnessed (before dying) Nezuko standing in the sun; which has changed Muzan's interest into devouring Nezuko to become perfect.
After his attack on the Ubayashiki Manor, Muzan escaped into the Infinity Fortress thanks to Nakime. It's revealed that Nakime has replaced Hantengu as the new Upper Moon Four and that Kaigaku (a former demon slayer and apprentice brother to Zenitsu Agatsuma) became the new Upper Moon Six to replace Gyutaro and Daki, after an encounter with Kokushibo. It's still currently unknown who the new Upper Moon Five is.
Shortly after arriving in the Infinity Fortress, Shinobu Kocho would stumble upon Upper Moon 2, Doma, feasting on his female cult followers in his chamber. A single woman survived, only to be mercilessly mutilated by Doma, despite Shinobu's hasty efforts to save her. The battle commenced between the Pillar and Upper Moon. However, Shinobu's assortment of poison proved to be useless against Doma's might. The demon would then proceed to promptly defeat and absorb the Pillar, only for Kanao Tsuyuri to arrive just too short of Doma finishing her.
Zenitsu later ran into Kaigaku and had a duel to the death with his former brother, resulting in Kaigaku's death and Zenitsu almost dying. Elsewhere in the fortress Tanjiro and Tomioka are located by Akaza. Akaza proved to be a fearsome opponent and nearly accomplished killing the two. Even after having cut off his head, Akaza through sheer willpower was able to keep his body from fading. Only through memories of his previous life as the human, Hakuji, and seeing visions of important figures of his past was he finally sedated and passed on.
Doma continues his fight against Kanao, who is unexpectedly later assisted by Inosuke Hashibira. He initially overwhelms the two with his ice attributed Demon Blood Techniques but was unexpectedly weakened by the lingering effects of Shinobu's wisteria flower poison after having absorbed her body. The two through their combined efforts were then able to detach Doma's head, putting an end to him.
Love Pillar, Mitsuri Kanroji and Snake Pillar, Obanai Iguro confront the newly appointed Upper Moon 4, Nakime. The demoness outwitted the pairs' attempts by the usage of her Blood Art that warps and controls the entire infrastructure of the Infinity Fortress Dimension as she sees fit. Simultaneously, the Mist Pillar, Muichiro Tokito was separated from the Rock Pillar, Gyomei Himejima by Nakime's ability, falling to the location of the highest-ranking demon, Upper Moon 1, Kokushibo.
Kokushibo instinctively sensed Muichiro because of his origin. Muichiro learns of his ancestral relation to Kokushibo, as well as of the demon's former occupation as a Demon Slayer after an examination of his inner body. Kokushibo, impressed by Muichiro's proficiency with his Breath Style, would then unsheathe his sword revealing his Breath of The Moon forms. The attack would sever Muichiro's left arm and he is swiftly defeated with minimal effort. Instead of killing the boy, Kokushibo offers to transform Muichiro into a demon as well due to intrigue in his blood relation and fighting ability. Genya Shinazugawa would attempt to ambush Kokushibo from behind using his shotgun in an attempt to save Muichiro, but his speed proved too formidable for the young slayer. Genya is immediately dismantled by the upper rank; both arms are sliced off and he is bifurcated from his waist. Noting Genya's similarity to Demon Slayers of similar physiology int he past, he knew the way to kill them by decapitation, like a Demon. However, before Kokushibo could administer the final blow, Genya is saved by the timely arrival of his older brother and the Wind Pillar, Sanemi Shinazugawa.
Sanemi manages to put up a fight against Kokushibo, albeit only for a short moment. After receiving injury from an attack Sanemi reveals that he is "Rare blood". He intended to use the intoxication of his premium blood as a distraction while fighting but to no avail. Using everything he could manage to think of and was at his wit's end; Sanemi is then almost killed by a barrage of blade swings. The pillar is saved by the intervention of his comrade, Gyomei Himejima.
| Upper Moon One|
| Upper Moon Two|
| Upper Moon Three|
| Upper Moon Four|
| Upper Moon Four|
| Upper Moon Five |
| Upper Moon Six |
| Upper Moon Six |
| Upper Moon Six |
| Lower Moon One |
| Lower Moon Two |
| Lower Moon Three |
| Lower Moon Four |
| Lower Moon Five |
| Lower Moon Six |
| Lower Moon Six |